Congratulations Zaighum Abbas for the PDB prize on the VI Latin American Crystallographic Association School and Meetin (VI LACA)!
Paper: Heterodimeric coiled coil
Our newest septin paper is out!
The X-ray structure of the hetero-coiled coil reveals interesting molecular details regarding septin-septin recognition and the features that facilitate their interaction with partners.https://t.co/pfVfaDE9eEWith the Crump Group and @WoolfsonLab
— Italo Cavini (@CaviniItalo) October 18, 2023
Paper: Cdc3-Cdc10 X-ray structure
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Best poster prize by Luis
PhD defense of Deborah Mendonça
Paper: Rationalization of the Borg’s BD3 binding site
AlphaFold came to change the game! Here, aided by an AF model, we have dissected the binding interface of Borg’s BD3 motif to the heterodimeric septin coiled coil SEPT6-SEPT7. It interacts with the furrow formed by the helices of the parallel CC. Upon binding in vitro, it leads to an exacerbated septin polymerization. The manuscript also contains polymerization studies on CTD-truncated septin subunits.
Access the publication here:
https://www.sciencedirect.com/science/article/abs/pii/S0022283623002048
