Herika D. A. Vidal, Paulo S. G. Nunes, Alice K. A. Martinez, Marcelo A. P. Januário, Pedro H. O. Santiago, Javier Ellena, Arlene G. Corrêa,
AbstractThe γ‐lactam ring is a prominent feature in medicinal chemistry, and its synthesis has garnered significant interest due to its valuable properties. Among the γ‐lactams, 2‐oxopyrrolidine‐3‐carbonitrile derivatives stand out as versatile synthons that can be readily transformed into a variety of other functional groups. In this work, we successfully synthesized highly functionalized 3‐cyano‐2‐pyrrolidinones with moderate to good overall yields using the Ugi reaction followed by intramolecular Michael addition. The process demonstrated excellent diastereoselectivity and showed good tolerance to a range of isonitriles and carbonyl compounds.
https://doi.org/10.1002/asia.202400917
@article{Vidal_2024, title={Diastereoselective Synthesis of Highly Functionalized γ‐Lactams via Ugi Reaction/Michael Addition}, ISSN={1861-471X}, url={http://dx.doi.org/10.1002/asia.202400917}, DOI={10.1002/asia.202400917}, journal={Chemistry – An Asian Journal}, publisher={Wiley}, author={Vidal, Herika D. A. and Nunes, Paulo S. G. and Martinez, Alice K. A. and Januário, Marcelo A. P. and Santiago, Pedro H. O. and Ellena, Javier and Corrêa, Arlene G.}, year={2024}, month=nov }